International Ki67 in Breast Cancer Working Group
Welcome to the International Ki67 in Breast Cancer Working Group
Who are we
In 2009, the International Ki67 in Breast Cancer Working Group of the Breast International Group and North American Breast Cancer Group formed to address the problem of inter-laboratory inconsistency in Ki67 assessment. It proposed guidelines for preanalytical and analytical conditions for Ki67 assessment, as well as for interpretation, scoring, and related data handling.1
1. Nielsen TO, Leung SCY, Rimm DL, et al. Assessment of Ki67 in Breast Cancer: Updated Recommendations from the International Ki67 in Breast Cancer Working Group. J Natl Cancer Inst. 2021 Jul 1;113(7):808-819. doi: 10.1093/jnci/djaa201. PMID: 33369635 .
Our Mission
- propose guidelines for preanalytical and analytical conditions for Ki67 assessment
- develop and disseminate standardized scoring methods for visual/manual scoring
- develop and disseminate standardized protocol for automated scoring
- to provide a centralized repository / hub to keep the community appraised of current research related to Ki67 as well as clinical practices involving Ki67.
Core Group
| Core Group | Affiliation |
| Mitch Dowsett (Chair) | Academic Department of Biochemistry, Royal Marsden Hospital / Institute of Cancer Research, UK |
| Daniel F. Hayes (Co-Chair) | Breast Oncology Program, Department of Internal Medecine, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States |
| Lisa M. McShane (Statistician) | National Cancer Institute, Bethesda, Maryland, USA |
| Kelley M. Kidwell (Statistician) | Department of Biostatistics, School of Public Health, University of Michigan |
| Torsten Nielsen (Pathologist) | Genetic Pathology Evaluation Centre, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada |
| Samuel Leung (Project Management) | Genetic Pathology Evaluation Centre, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada |
Working Group
| Working Group | Affiliation |
| Balazs Acs | Karolinska Institutet, Stockholm, Sweden |
| Indu Arun | Tata Medical Center, Kolkata, West Bengal, India |
| Renaldas Augulis | Vilnius University Hospital Santara Clinics, Vilnius University, Vilnius, Lithuania |
| Sunil S. Badve | Indiana University Simon Cancer Center, Indianapolis, Indiana, USA |
| Yalai Bai | Yale University School of Medicine, New Haven, Connecticut, USA |
| Anita L. Bane | Juravinski Hospital and Cancer Centre, McMaster University, Hamilton, Ontario, Canada |
| John M.S. Bartlett | Ontario Institute for Cancer Research, Toronto, Ontario, Canada |
| Jane Bayani | Ontario Institute for Cancer Research, Toronto, Ontario, Canada |
| Gilbert Bigras | University of Alberta, Edmonton, Alberta, Canada |
| Signe Borgquist | Skane University Hospital, Lund University, Lund, Sweden |
| Martin C. Chang | Sinai Health System, University of Toronto, Toronto, Ontario, Canada |
| Carsten Denkert | Charité Campus Mitte, Berlin, Germany |
| Andrew Dodson | The Institute of Cancer Research, London, United Kingdom |
| Anna Ehinger | Skane University Hospital, Lund University, Lund, Sweden |
| Susan Fineberg | Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York, USA |
| Cornelia M. Focke | Dietrich-Bonhoeffer Medical Center, Neubrandenburg, Mecklenburg-Vorpommern, Germany |
| Chad Galderisi | MolecularMD, Portland, Oregon, USA |
| Dongxia Gao | University of British Columbia, Vancouver, British Columbia, Canada |
| Abhi Gholap | Optra Technologies, NeoPro SEZ, BlueRidge, Hinjewadi, India |
| Allen M. Gown | PhenoPath Laboratories, Seattle, Washington, USA |
| Carolina Gutierrez | Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA |
| Douglas J. Hartman | University of Pittsburgh, Pittsburgh, Pennsylvania, USA |
| Judith C. Hugh | University of Alberta, Edmonton, Alberta, Canada |
| Anagha Jadhav | Optra Technologies, NeoPro SEZ, BlueRidge, Hinjewadi, India |
| Elizabeth N. Kornaga | Tom Baker Cancer Centre, Alberta Health Services, Calgary, Alberta, Canada |
| Zuzana Kos | The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada |
| Anne-Vibeke Lænkholm | Zealand University Hospital, Slagelse, Region Sjælland, Denmark |
| Arvydas Laurinavicius | Vilnius University Hospital Santara Clinics, Vilnius University, Vilnius, Lithuania |
| Richard Levenson | University of California Davis Medical Center, Sacramento, California, USA |
| Keith Miller | Poundbury Cancer Institute, Poundbury, Dorset, United Kingdom |
| Takuya Moriya | Kawasaki Medical School, Kurashiki, Okayama Prefecture, Japan |
| Sharon Nofech-Mozes | University of Toronto Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada |
| C. Kent Osborne | Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA |
| Liron Pantanowitz | University of Pittsburgh, Pittsburgh, Pennsylvania, USA |
| Frédérique M. Penault-Llorca | Centre Jean Perrin and Université d'Auvergne, Clermont-Ferrand, France |
| Tammy Piper | Edinburgh Cancer Research Centre, Western General Hospital, Edinburgh, United Kingdom |
| Jason Ruan | University of California Davis Medical Center, Sacramento, California, USA |
| Takashi Sakatani | Nippon Medical School, Bunkyo-ku, Tokyo, Japan |
| Roberto Salgado | Institut Jules Bordet, Brussels, Belgium |
| Melanie Spears | Ontario Institute for Cancer Research, Toronto, Ontario, Canada |
| Malini Srinivasan | University of Pittsburgh, Pittsburgh, Pennsylvania, USA |
| Jane Starczynski | Birmingham Heart of England, National Health Service, Birmingham, United Kingdom |
| Tomoharu Sugie | Kansai Medical University, Hirakata, Osaka, Japan |
| Austin Todd | University of California Davis Medical Center, Sacramento, California, USA |
| Bert van der Vegt | University Medical Center Groningen, Groningen, The Netherlands |
| Giuseppe Viale | University of Milan, Milan, Italy |
| Shakeel Virk | Queen's University, Kingston, Ontario, Canada |
| Yihong Wang | Rhode Island Hospital, Brown University, Providence, Rhode Island, USA |
| Ying Wu | Juravinski Hospital and Cancer Centre, McMaster University, Hamilton, Ontario, Canada |
| Lila A. Zabaglo | The Institute of Cancer Research, London, United Kingdom |
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This website was made possible by a generous grant from the Breast Cancer Research Foundation.